Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability among other NSAIDs in its class.
Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.
Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.
Nimesulide is available in various forms like powder/granules, gel, and suppositories.
A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )
Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.
No comments:
Post a Comment