Nimesulide tablet
was launched in Italy for
the first time as Aulin and Mesulid in 1985 and is presently
available in more than 50 countries worldwide.
It is available
in a variety of forms: tablets, powder for dissolution in water,
suppositories, mouth dissolving tablets and topical gel.
Nimesulide
undergoes extensive biotransformation. Nimesulide has a relatively
rapid onset of action, with meaningful reductions in pain and
inflammation observed within 15 minutes from drug intake.
Food, gender and
advanced age have negligible effects on Nimesulide pharmacokinetics.
The usual dose is
100mg twice a day. The duration is recommended to use for 15 days.
Continuous use of nimesulide tablet (more than
15 days) can cause the side effects of Diarrhea, skinrash.
Advantages for the treatment of Nimesulide:
- Nimesulide has less gastrointestinal adverse effects than other NSAIDs
- It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
- Its multifactorial mode of action gives it a unique and broad action on inflammatory.
- Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
- Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities
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