Nimesulide drug

Nimesulide is an NSAID and a preferential COX II inhibitor. It is a potent analgesic, antipyretic, and potent Anti-Inflammatory action.

Pharmacokinetic:

It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Nimesulide does not have significant gastroduodenal side effects. The onset of analgesic and antipyretic action of oral nimesulide is 1.6–3.17 h and duration of action is 10–12 h.

Absorption:

Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Nimesulide Drug uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide medicine uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders

Nimesulide a specific Cox-2 anti-inflammatory medication which have been turned out to be fundamentally more suitable in giving symptomatic alleviation for intense agony, symptomatic treatment of horrifying degenerative joint sickness and first dysmenorrhoea.

The European Medicines Agency has finished an review of the security and viability of solutions containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

Usage of Nimesulide 100mg- Tablet:

Nimesulide has less gastrointestinal adverse effects than other NSAIDs
It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
Its multifactorial mode of action gives it a unique and broad action on inflammatory.
Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Nimesulide tablet uses

Nimesuilde is a pain killer NSAIDs drug best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with Osteoarthritis, Postoperative trauma, Sports injuries, Ear, Nose and Throat disorders, Dental surgery, Bursitis/Tendinitis, Thrombhophlebitis, Pharyngitis and Gynaecological disorders.

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide Tablet is also used for:

• Rapid onset of action within 15 minutes
• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms

Precautions:

• Women should use the drug with caution during lactation; Nimesulide is contraindicated during pregnancy.
• The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide tablet synthesis

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. 

The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Tablet shows the result from pain within 15min from the drug intake
Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg.

Nimesulide mechanism of action

Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode of action, characterized by a fast onset of analgesic activity.It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations included in the Summary of Product Characteristics.

In 1980 the original nimesulide molecule was in-licensed by Helsinn Healthcare, a pharmaceutical company based in Switzerland. In 1985 it was first launched in Italy by Helsinn’s local licensees under the brand names Aulin and Mesulid. 

Helsinn manufactures the original Nimesulide active ingredient and finished products in full compliance with the current Good Manufacturing Practice (cGMP) guidelines in its plants in Switzerland and Ireland.

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide multifactorial approach

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs with multi factorial approach for treating post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

It was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide in different trademarks

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It is available in the market in various like tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The Gel needed to be applied is three to four times per day depending on the dimension of the affected size and response. Medicalcare ought to be reviewed after 4 weeks.

Trademarks of NImesulide include of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

Nimulid Transgel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nise tablet benefits

“Nise” tablet is a trademark for the drug “Nimesulide" which is a multifactorial approachcharacterized by a fast onset of analgesic activity.

Nise tablet shows significant progress in the treatment post-traumatic inflammation, acute musculoskeletal disorders, and osteoarthritis (joint pains).

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It is available in the form of capsule, tablet and gel with the dosage of 100mg. Nice tablet shows instant pain relief from acute pain.

The Gel is needed to be applied for three to four times per day depending on the dimension of the affected size and response. Medicalcare ought to be reviewed after 4 weeks.

It should be used under supervision of a doctor, It is prescribed to use for the age above 12years and the duration should be maximum of 15 days