Nimesulide drug information

Nimesulide medication developed by Helsinn Healthcare is a non-steroidal anti-inflammatory drug, indicated for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide tablets are authorised in a number of Member States. They are only available with a prescription.

It also used for the treatment of
Skin Tone
Heart Disease
Dry Skin

It posses anti-inflammatory and analgesic properties. it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous environment.

The Nimesulide Tablets are highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide gel uses

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Original Nimesulide is commercially available as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

The anti-inflammatory activity of topically applied Nimesulide gel commonly used in the management of Musculoskeletal injuries.

Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.

The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.

Nimesulide transdermal gel is a novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features:

Amongst most effective yet gastro friendly
Non steroidal anti inflammatory drug (NSAID)
Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Uses of Nimesulide:
Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication.
Rapid onset of action within 15 minutes
Rapidly relieves pain in arthritis

Nimesulide solubility

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment, it also hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

A variety of Nimesulide forms are available in the market like in the form of tablets, suppositories and syrup for oral administration and gels for topical application.

Nimesulide suppositories is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide, a wide proposed drug pain relieving medication has a place with sulfonanilide class II and show low and variable oral bioavailability. Nimesulide tablets is generally utilized in inflammatory pain.

nimesulide is an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity.As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide gel

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

Nimesulide is used topically as an analgesic with NSAID benefits and functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms.

The anti-inflammatory activity of topically applied Nimesulide gel commonly used in the management of Musculoskeletal injuries.

Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.

The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.

Nimesulide transdermal gel is a novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

Nimesulide forms

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide which is used for for treating post-traumatic inflammation, acute musculoskeletal disorders.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide benefits

NSAID drug Nimesulide has a favourable benefits and it has proven benefits in the treatment of pain

Medicines containing Nimesulide are on the market since 1985 and are authorised in a number of Member States.

The main purpose of using NImesulide is to treat acute pain, to treat arthritis, and treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide dose ought to be taken by prescription of medico and doctor which is able to facilitate to take proper dose for good result. Women should use the drug with caution during lactation and it is contraindicated during pregnancy.

NSAIDs prescribed painkiller drug- Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

• Nimesulide is also used to:

• Increase in energy
• Improve skin tone
• Heart disease
• Dry skin
• Nimesulide Dosage:
  Adults: 100 mg twice daily
  Children: 5mg/kg of body weight in 2 or 3 divided doses.
  
  

Nimesulide medicine for osteoarthritis

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

It undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.